Figure 1. Design of fluorescent TALEs specific for either strand of the human telomeric DNA sequence. The repeating amino acid elements of the two illustrated fluorescent TALEs were designed²⁰ to recognize either the “L” or “R” strand of the telomere sequence. The plasmids encoding these TALEs were constructed with in-frame Venus (yellow) or mCherry (red) fluorescent proteins at the C-termini. Reproduced from reference 11 by permission of the Proceedings of the National Academy of Sciences.