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. Author manuscript; available in PMC: 2015 Apr 1.
Published in final edited form as: Curr Opin Virol. 2014 Feb 16;0:24–33. doi: 10.1016/j.coviro.2014.01.005

Figure 4. Structures of the NDV and PIV5 HN ectodomain and stalk regions.

Figure 4

(A) The NDV HN crystal structure (PDB ID: 3TIE) [56] representing the “4-heads-down” conformation is shown in cartoon format. Active site residues (E400, R415, and Y525) are shown as yellow, blue and red spheres. The locations of the second sialic acid binding sites are not shown. The stalk/RBD interface is circled and labeled. (B) Structure of the PIV5 HN 4HB stalk domain encompassing residues 56-108 (PDB ID code 3TSI) [47] . Residues in ‘a’ ‘d’ and ‘h’ positions of the hydrophobic core of the 4-helix bundle (yellow) are numbered. (C) Structure of the “2-heads-up/2-heads-down” conformation revealed by the PIV5-HN ectodomain crystal structure (PDB ID code 4JF7) [57]. The two dimers of RBD head domains (2-heads up and 2-heads down) are indicated.