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. Author manuscript; available in PMC: 2015 Jun 1.
Published in final edited form as: Acta Neuropathol. 2013 Dec 3;127(6):881–895. doi: 10.1007/s00401-013-1218-2

Table 1.

Tissue Specimens used for Molecular Analyses

Patient
ID		 Diagnosis Gender Age Type c.83 A→T
(K27M) Status		 Normal
Tissue
Origin		 Protein
Analysis		 mRNA
Analysis		 DNA
Methylation
Analysis
H3F3A HIST1H3B
1 DIPG M 8y PM WT MT Brainstem T, N - T, N
2 DIPG F 6y PM MT - Brainstem T, N T T, N
3 DIPG F 7y PM - - Brainstem T, N T, N -
4 DIPG M n/a PM MT - - T T -
5 DIPG M n/a PM MT - - T T -
6 DIPG F 14y PM MT - Brainstem T, N T, N T, N
7 DIPG F 5y PM MT - Brainstem T, N T, N T, N
8 DIPG M n/a PM WT MT Brainstem T, N T, N T, N
9 DIPG F 4y PM WT WT - T T -
10 DIPG M 8y PM MT - Brainstem T, N T, N T, N
11 DIPG M 8y PM MT - Brainstem T, N T, N T, N
12 DIPG n/a n/a PM MT - - T T -
13 DIPG M 21y PM WT WT Frontal
Lobe		 T, N T, N T, N
14 DIPG M 6y PM WT WT Frontal
Lobe		 T, N T, N T, N
15 Astrocytoma M 15y OR WT WT Frontal
Lobe		 T, N T, N -
16 Astrocytoma M 15y OR WT WT - T T -
17 Astrocytoma M 7y PM n/a - - T - -
18 Astrocytoma M 25y PM WT WT - T T -
19 Astrocytoma (GBM) F 6y PM WT MT Frontal
Lobe		 T, N - T, N
20 Astrocytoma (GBM) M 25y PM MT - T T -
21 Astrocytoma (GBM) M 18y PM WT WT - T T -
22 Astrocytoma (GBM) M 18y PM MT - Frontal
Lobe		 T, N T, N -
23 Juvenile Pilocytic Astrocytoma M 5y OR WT - - T T -
24 Juvenile Pilocytic Astrocytoma M 21y PM WT - - T T -
25 Ependymoma M 3y OR WT - - T T -
26 Ependymoma M 15y OR WT - - T T -
27 Ependymoma M 6m OR WT - - T T -
28 Medulloblastoma M 15y OR WT - - T T -
29 Medulloblastoma F 8y OR WT - - T T -
30 Glioneural Tumor F 2y PM WT - - T T -
31 Meningioma F 11y OR WT - - T T -
TOTAL PATIENTS 31 29 10 13 31 28 10