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E2f1tm1 mice display a significant reduction in the number of doublecortin-positive cells in the OB and dentate gyrus of HC. A) Coronal OB and HC sections from WT and E2f1tm1 P365+ animals immunolabeled with DCX in red. In HC sections, the dentate gyrus is outlined with dashed lines. B) Quantification reveals a strong reduction in the number of newly generated DCX-positive neurons. All data are represented as mean ± SEM. * Student’s t-test; α ≤ 0.05.
