Skip to main content
. 2014 Feb 11;5:34–41. doi: 10.1016/j.coviro.2014.01.009

Figure 3.

Figure 3

Conserved structural features in class II fusion proteins. (a) Gc from Rift Valley fever virus (RVFV) crystallizes in a dimeric head-to-tail configuration [5••]. The Gc dimers are strikingly similar to the flavivirus E dimers (dengue type 2 E shown here [12]). E dimers are the building block of the icosahedral outer protein shell in flaviviruses [26]. (b) The fusion loop serves as the anchor in the target cellular membrane during the fusion reaction (see Figure 2). The structure of the fusion loop is highly conserved in class II fusion proteins. Shown here are the fusion loops of, from left to right, RVFV Gc [5••], Sindbis virus (SINV) E1 [20], West Nile virus (WNV) E [13], and rubella virus (RV) E1 [6••].