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. Author manuscript; available in PMC: 2015 Jun 1.
Published in final edited form as: Reprod Toxicol. 2014 Jan 9;45:45–51. doi: 10.1016/j.reprotox.2014.01.002

Figure 3. Effect of co-treatment with MEHP and E2 on the expression of mRNAs that encode proteins that favor apoptosis.

Figure 3

Mouse antral follicles were isolated, treated with vehicle, MEHP, E2, or MEHP and E2 for 48 h, and processed for qPCR gene expression analysis (see sections 2.4 and 2.6 for details). Data represent mean relative expression ± SEM obtained from three separate culture experiments, each with 12 follicles per treatment. Statistical significance was set at p≤0.05 and difference between treatments and vehicle are indicated by the asterisks. Trends between a treatment and vehicle are indicated by the actual p-value (e.g., p=0.06). (A) expression of Aifm1 (mitochondrial apoptosis-inducing factor 1) and (B) expression of Bok (BCL2-related ovarian killer protein).