Forced expiratory volume 1.0 s (FEV1.0) and forced expiratory flow at 50% forced vital capacity (FEF50%) in control and asthmatic subjects at baseline and following an intervention during four experimental trials: control; bronchodilation (BD); sham (SHAM); and bronchoconstriction (BC). A) FEV1.0 at baseline and following each of four interventions in control subjects; B) FEV1.0 at baseline and following each of four interventions in asthmatic subjects; C) FEF50% at baseline and following each of four interventions in control subjects; D) FEF50% at baseline and following each of four interventions in asthmatic subjects. Note that FEV1.0 and FEF50% were lower in asthmatic subjects compared with control subjects. Also, note the marked changes in FEV1.0 and FEF50% following BD and BC in asthmatic subjects. *, p<0.05 vs. control group; †, p<0.05 vs. baseline; a, p<0.05 vs. CON trial; b, p<0.05 vs. BD trial; c, p<0.05 vs. SHAM trial.