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Reduction of Aβ plaque deposition by the anti-apoE antibody HJ6.3. Seven-month-old female APP/PS1 mice received 10 mg/kg weekly intraperitoneal injections of HJ6.3 or PBS for 21 weeks. A, Brain sections of the HJ6.3- or PBS-treated mice were stained with the anti-Aβ antibody HJ3.4B. Scale bar, 1 mm. B, Aβ plaque load in cortex, thalamus, and hippocampus were quantified (n = 13–17/group; *p < 0.05).
