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Effects of the anti-apoE antibody HJ6.3 on brain apoE. Seven-month-old female APP/PS1 mice received 10 mg/kg weekly intraperitoneal injections of HJ6.3 or PBS for 21 weeks. ApoE in the cortex of the HJ6.3- or PBS-treated mice was immunostained with HJ6.8B (A) and the percentage area covered by the staining was quantified (B) (n = 15–18/group; *p < 0.05; **p < 0.01). Scale bar, 400 μm.
