Figure 6.

HJ6.3 treatment improved spatial learning performance in the MWM. Seven month-old female APP/PS1 mice received 10 mg/kg weekly intraperitoneal injections of HJ6.3 or PBS for 21 weeks until 12 months of age. During the last 4 weeks of treatment, the performance of HJ6.3-treated (n = 19) and PBS-treated (n = 18) mice in the MWM task was tested. A, The HJ6.3- and PBS-treated mice did not differ in performance with regard to path length during the cued trials. B, However, the HJ6.3-treated mice exhibited significantly improved performance in terms of showing decreased path length during the place (spatial learning) trials compared with the PBS-treated group (treatment effect: *p = 0.035), with differences being greatest during block 3 (†p = 0.019). C, PBS-treated mice did not show a spatial bias for the target quadrant during the probe trial because they did not spend significantly more time in that quadrant compared with the times in each of the other quadrants. In contrast, the HJ6.3-treated mice did show a spatial bias for the target quadrant because they spent significantly more time in the target quadrant compared with the times spent in each of the other pool quadrants (*p < 0.014).