Figure 8.

No effects of HJ6.3 on plasma cholesterol, CAA, or CAA-associated microhemorrhage. Seven-month-old APP/PS1 mice received 10 mg/kg weekly intraperitoneal injections of HJ6.3 or PBS for 21 weeks until 12 months of age. A, Total plasma cholesterol levels. B, CAA on the surface of the cortex was identified by anti-Aβ antibody HJ3.4B immunostaining and the area covered by CAA was quantified. C, CAA-associated microhemorrhage was detected by Prussian blue and ThioS costaining (n = 13–18/group).