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Distribution volume images of [11C] raclopride at the level of the striatum in a normal control and a detoxified cocaine-dependent subject tested after placebo (baseline) and after methylphenidate (MP) administration. Baseline binding for [11C]raclopride is reduced in the addicted subject, and changed less with an MP challenge than the normal subject, suggesting a persistent change in the brain receptor density due to prior cocaine exposure (adapted from [9], with permission).
