Skip to main content
. Author manuscript; available in PMC: 2014 May 21.
Published in final edited form as: Dev Neurobiol. 2012 Jun;72(6):918–936. doi: 10.1002/dneu.20978

Fig. 10.

Fig. 10

Modulation of pituitary adenylate cyclase activating polypeptide (PACAP; A) and vasoactive intestinal polypeptide (VIP; B) transcript expression in littermate wildtype (WT) and synuclein overexpressing (SYN-OE) mice in micturition reflex pathways, superior cervical ganglia (SCG) and brain. WT samples were set equal to 100% and normalized to the relative expression of the reference gene, L32. SYN-OE samples were expressed relative to WT samples and normalized to the relative expression of the reference gene, L32. A) PACAP mRNA expression in tissues sampled (L6-S1 dorsal root ganglia (DRG), L6-S1 spinal cord, SCG, major pelvic ganglia (MPG) and brain). PACAP transcript expression significantly (p ≤ 0.01) increased all tissues examined in SYN-OE mice that demonstrated amplification of PACAP transcript except SCG. No amplification of PACAP transcript was observed in the urothelium or detrusor smooth muscle of the urinary bladder. B) VIP mRNA expression in tissues sampled (urothelium, detrusor smooth muscle, L6-S1 DRG, L6-S1 spinal cord, SCG, MPG and brain). VIP transcript expression significantly (p ≤ 0.01) increased in all tissues examined in SYN-OE mice except S1 DRG. Values are mean ± SEM. *, p ≤ 0.01 versus WT.