Fig. 2.

SYN-OE mice exhibit altered locomotor function with advancing age. Wildtype (WT) and synuclein overexpressing (SYN-OE) mice littermates were tested at 16 and 32 rpm on consecutive days on a motorized rotating rod. SYN-OE maintain motor activity on the rod comparable to littermate WT mice when the rod rotated at 16 or 32 rpm from 1 month of age through 10 months of age. Beginning at 11 months of age, SYN-OE mice fall significantly (p ≤ 0.01) faster (decreased latency to fall) at 16 and 32 rpm compared to littermate WT mice. This decreased latency to fall exhibited by SYN-OE mice persisted through the end of the testing period (17 months of age). *, p ≤ 0.01 relative to WT at 16 rpm; #, p ≤ 0.01 relative to WT at 32 rpm.