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. Author manuscript; available in PMC: 2014 May 21.
Published in final edited form as: Dev Neurobiol. 2012 Jun;72(6):918–936. doi: 10.1002/dneu.20978

Fig. 5.

Fig. 5

Urinary bladder dysfunction onset precedes motor dysfunction in SYN-OE mice. Urinary bladder dysfunction was observed in SYN-OE mice at 4 months of age and persisted to the last age studied (16 months of age). The presence (score of 1) of urinary bladder dysfunction preceded motor dysfunction by 7 months in SYN-OE mice. Motor dysfunction was not observed (absence; score of 0) in SYN-OE evaluated using rotarod testing (Fig. 2) and gait analyses (Fig. 3) from 1-10 months of age. Urinary bladder dysfunction was not observed (absence; score of 0) using conscious cystometry in SYN-OE mice evaluated from 1-3 months of age.