. Author manuscript; available in PMC: 2014 May 21.

Published in final edited form as: J Thorac Oncol. 2014 Mar;9(3):324–336. doi: 10.1097/JTO.0000000000000090

TABLE 1.

Proteins Overexpressed in Small-Cell Lung Cancer, Membrane-Associated, and with Functions Relevant to Cancer Progression and/or Neuroendocrine Phenotype and/or Part of Networks Related to Cell/Tissue Morphology

Protein Symbol	Gene Symbol	Overexpressed in SCLC (N = 83)		Membrane-Associated (N = 32)	Interesting Functions for SCLC Progression (N = 17)			Final Candidate Biomarkers (N = 5)
Protein Symbol	Gene Symbol	Av. Ratio	t test	Membrane-Associated (N = 32)	Relevant to Cancer Progression	Relevant to Neuroendocrine Phenotype	Part of Cell/Tissue Morphology Networks	Final Candidate Biomarkers (N = 5)
PRDX2	PRDX2	7.23	2.90E–11	x	x		x
STMN1	STMN1	5.71	1.30E–12	x	x	x	x	x
HNRPC	HNRNPC	5.38	8.90E–10
FPPS	FDPS	4.68	1.80E–09
STRAP	STRAP	4.68	1.80E–09	x	x
PSA1	PSMA1	4.18	3.10E–12
ATD3A	ATAD3A	3.92	4.90E–09	x
ERO1A	ERO1L	3.92	4.90E–09	x
G3BP1	G3BP1	3.92	4.90E–09	x
HSP71	HSPA1A-1B	3.92	4.90E–09
	MIR7-1	3.92	4.90E–09
HMGB1	HMGB1	3.67	6.90E–07
CALD1	CALD1	3.55	1.80E–09	x	x		x
SPF27	BCAS2	3.44	8.50E–13
ROAA	HNRNPAB	3.31	1.70E–08
CAPG	CAPG	3.06	2.40E–09	x			x
RS10	RPS10	3.06	5.90E–05
DPYL2	DPYSL2	2.73	4.10E–08	x	x	x	x	x
TCPG	CCT3	2.73	4.10E–08
AL9A1	ALDH9	2.72	4.50E–10
EFR1	ERVFRDE1	2.72	4.50E–10	x
IF2B	EIF2S2	2.72	4.50E–10
ODO2	DLST	2.72	4.50E–10	x
PTBP1	PTBP1	2.72	4.50E–10
RUVB2	RUVBL2	2.72	4.50E–10	x	x
SPF45	RBM17	2.72	4.50E–10
UAP56	BAT1	2.72	4.50E–10
BUB3	BUB3	2.71	2.50E–08
PCBP1	PCBP1	2.71	2.50E–08
RBM4B	RBM4B	2.71	2.50E–08
RSSA	RPSA	2.71	2.50E–08	x	x	x	x	x
EIF3H	EIF3H	2.69	3.10E–10
AHNK	AHNAK	2.64	2.40E–07
HSP7E	HSPA14	2.64	2.40E–07
IF5	EIF5	2.64	2.40E–07
SFRS6	SFRS6	2.64	2.40E–07
TCPQ	CCT8	2.64	2.40E–07
ARP2	ACTR2	2.62	1.40E–06
PURA	PURA	2.62	1.40E–06
AMPL	LAP3	2.61	4.20E–09
CSTF1	CSTF1	2.61	4.20E–09
ODB2	DBT	2.61	4.20E–09
RUVB1	RUVBL1	2.61	4.20E–09	x	x			x
CT007	C20orf7	2.56	6.00E–05	x
OCAD1	OCIAD1	2.42	2.80E–05
SYYC	YARS	2.39	2.80E–05
FUBP2	KHSRP	2.29	0.00059
DNJC3	DNAJC3	2.14	6.20E–07
GLSK	GLS	2.14	6.20E–07
PRDX4	PRDX4	2.14	9.50E–06	x	x
PRP19	PRPF19	2.14	6.20E–07
ARSA1	ASNA1	2.1	3.80E–08	x
FKBP8	FKBP8	2.03	6.30E–08	x		x	x
HNRH1	HNRNPH1	2.03	6.30E–08
TBB5	TUBB	2.03	6.30E–08	x			x
CH60	HSPD1	1.97	2.60E–05	x	x		x
NONO	NONO	1.97	2.60E–05
SF3A3	SF3A3	1.97	2.60E–05
TBL1R	TBL1XR1	1.97	2.60E–05
TPR	TPR	1.92	0.0006	x			x
ACTB	ACTB	1.9	2.60E–06
RANG	RANBP1	1.9	2.60E–06
ACON	ACO2	1.83	3.40E–05
EFG2	GFM2	1.83	3.40E–05
IMMT	IMMT	1.83	3.40E–05	x
MIRO2	RHOT2	1.83	3.40E–05	x
PLOD3	PLOD3	1.83	3.40E–05	x			x
XRCC5	XRCC5	1.83	3.40E–05	x
CORO1A	CORO1A	1.82	2.80E–05	x	x		x
DLDH	DLD	1.82	2.80E–05
SCOT1	OXCT1	1.82	2.80E–05
EIF3G	EIF3G	1.81	6.00E–07
SCMC1	SLC25A24	1.81	6.00E–07	x
TADBP	TARDBP	1.81	6.00E–07
GNAQ	GNAQ	1.75	2.50E–05	x	x	x	x	x
IDH3B	IDH3B	1.75	2.50E–05
UBFD1	UBFD1	1.75	2.50E–05
RBBP7	RBBP7	1.73	0.0056
ATPB	ATP5B	1.65	4.90E–05	x
TPD52	TPD52	1.65	0.00054	x
KAP2	PRKAR2A	1.62	0.00062	x
PDIA6	PDIA6	1.62	0.00062	x
PCBP2	PCBP2	1.56	3.80E–06

SCLC, small-cell lung cancer.

Bold indicates candidate biomarkers.