Prospective associations of social support with inflammation (N = 647)
| Family support | Friend support | Spouse support | Total support | |||||
|---|---|---|---|---|---|---|---|---|
| Coef. (SE) | BIC | Coef. (SE) | BIC | Coef. (SE) | BIC | Coef. (SE) | BIC | |
| C-reactive protein (log) | ||||||||
| Age & sex adjusted | 0.03 (0.08) | 1930.22 | −0.04 (0.08) | 1930.05 | −0.17* (0.09) | 1927.03 | −0.10 (0.10) | 1929.27 |
| Fully adjusteda | 0.12 (0.08) | 1807.54 | 0.08 (0.06) | 1808.71 | −0.02 (0.08) | 1810.09 | 0.08 (0.09) | 1809.22 |
| Fibrinogen | ||||||||
| Age & sex adjusted | −3.87 (6.91) | 7497.60 | −6.67 (5.24) | 7496.54 | −7.12 (6.63) | 7496.89 | −11.05 (7.32) | 7496.35 |
| Fully adjusteda | 1.42 (7.06) | 7521.13 | −0.88 (5.23) | 7521.16 | −0.66 (6.34) | 7521.18 | −1.83 (7.35) | 7521.19 |
| IL-6 (log) | ||||||||
| Age & sex adjusted | −0.06 (0.06) | 1396.03 | −0.07 (0.05) | 1395.44 | −0.12* (0.06) | 1393.53 | −0.12* (0.07) | 1394.01 |
| Fully adjusteda | 0.00 (0.06) | 1367.14 | 0.00 (0.05) | 1367.15 | −0.03 (0.06) | 1366.87 | 0.00 (0.07) | 1367.15 |
| E-selectin (log) | ||||||||
| Age & sex adjusted | −0.01 (0.04) | 1045.22 | 0.01 (0.03) | 1045.18 | −0.05 (0.05) | 1044.10 | −0.02 (0.06) | 1045.20 |
| Fully adjusteda | 0.01 (0.04) | 1080.32 | 0.05 (0.03) | 1078.56 | −0.01 (0.05) | 1080.33 | 0.03 (0.05) | 1080.00 |
| ICAM-1 | ||||||||
| Age & sex adjusted | −11.39 (8.89) | 7758.28 | −17.99** (7.47) | 7753.49 | −16.20** (8.02) | 7756.71 | −19.33** (8.73) | 7753.04 |
| Fully adjusteda | −7.39 (8.84) | 7787.69 | −12.68* (7.38) | 7784.98 | −10.38 (8.07) | 7787.01 | −10.20 (8.64) | 7785.06 |
***
p < 0.01,
**
p < 0.05,
*
p < 0.1; two-tailed test.
a
Controls for age, sex, SNS activity (creatinine-adjusted epinephrine and norepinephrine levels), household income, education, BMI, current smoking status, and medications.