Skip to main content
. Author manuscript; available in PMC: 2015 Jun 28.
Published in final edited form as: Cancer Lett. 2014 Mar 21;348(0):156–166. doi: 10.1016/j.canlet.2014.03.016

Figure 7. Schematic diagram of the mechanism by which a combination of TRAIL and triptolide cause cell death in pancreatic cancer cells.

Figure 7

Triptolide treatment sensitizes cells to TRAIL-induced death by down-regulation of c-FLIP and up-regulation of DR5. Finally, in the presence of triptolide, low concentration of TRAIL activated the death receptor pathway, resulting in LMP and MOMP mediated pancreatic cancer cell death.