Table 1.
Summary of SiR based companion imaging drug with Olaparib.
| Compound | # | MW | ClogP | Charge (pH 7.0) | Abs (nm) | Em (nm) | IC50 (nM) | Live Cell permeability |
|---|---|---|---|---|---|---|---|---|
| SiR-Me | 4 | 443.63 | −0.13 | 0 | 649 | 672 | NA | Yes |
| SiR-COOH | 9 | 473.62 | −0.88 | −1 | 645 | 676 | NA | No |
|
| ||||||||
| Olaparib-SiR-Me | 6 | 792.01 | 4.23 | +1 | 653 | 675 | 99.2±9.8 | Yes |
| Olaparib-SiR-COOH | 10 | 821.99 | 3.74 | 0 | 653 | 670 | 100.3±9.8 | Yes |
| Olaparib-spacer-SiR-COOH | 14 | 978.17 | 3.59 | 0 | 653 | 678 | 112.9±9.6 | Yes |
|
| ||||||||
| Olaparib[8] | 434.46 | 1.24 | 0 | NA | NA | 5 | Yes | |
| Olaparib-BODIPY-FL[2] | 640.46 | 4.8 | 0 | 507 | 525 | 12.2±1.1 | Yes | |
| Olaparib-TCO/Tz-TR[13] | 1535.6 | 5.15 | −1 | 595 | 615 | 15.4±1.2 | No | |