Table 1.

Potential miRNA target genes identified with PUBMED and miRWalk with gene product functions determined by GO biologic process.

miRNA	Target gene	Gene product function	GO Term (Accession, Ontology)
hsa-miR-181a	TLR-4	Toll-like receptor-4 (TLR) plays a fundamental role in pathogen recognition and activation of innate immunity	GO:0035662, Molecular Function
	IL-6	Acute and chronic inflammation and the maturation of B cells; T helper (Th)17 differentiation	GO:0019981, Molecular Function
	DUSP5 DUSP6 PTPN11 PTPN22	Regulation of early B/T cell development; Positive regulation of T Cell Receptor (TCR)-signalling; Determination of T helper (Th) subset differentiation; Establishment of central tolerance/autoimmunity	GO:0070373, Biological Process
hsa-miR-181b	IL-6	Negative regulation of cytokine secretion; negative regulation of collagen biosynthetic process; positive regulation of acute inflammatory response; response to cold, heat and mechanical stimuli; T Helper (Th)17 differentiation	GO:0005138, Molecular Function
	CCL8	Immune response, inflammatory response, chemokine activity, phospholipase activator
	MMP9	Cell response to IL-1, LPS; macrophage differentiation; response to heat and mechanical stimuli; positive regulation of apoptosis and angiogenesis	GO:0004229, Molecular Function
	TGFB1	Adaptive immune response; positive regulation of collagen biosynthesis, chemotaxis, fibroblasts migration, and ondontogenesis; T helper (Th)17 differentiation, T regulatory (Treg) differentiation	GO:0034713, Molecular Function
hsa-miR-181c	SOCS1	Cytokine mediated signaling pathway; negative regulator of JAK-STAT pathway; LPS response
	IL-2	Cytokine produced by T-cells in response to antigen or mitogen stimulation	GO:0005134, Molecular Function
hsa-miR-24	MAPK14	MAP kinase activated by various environmental stresses and proinflammatory cytokines, act as an integration point for multiple biochemical signals	GO:0051403, Biological Process
hsa-miR-95	EIF2C2	Eukaryotic translation initiation factor interacted with dicer1 in short- interfering-RNA-mediated gene silencing
hsa-miR-149	VEGFA	Increased vascular permeability, angiogenesis, vasculogenesis and endothelial cell growth, promoting cell migration, and inhibiting apoptosis	GO:0035924, Biological Process
has-miR-455	IL-10	Pleiotropic effects in immunoregulation and inflammation, B cell survival, proliferation, and antibody production, block NF-kappa B activity	GO:0019969, Molecular Function
	TLR-4	Toll-like receptor-4 (TLR) plays a fundamental role in pathogen recognition and activation of innate immunity	GO:0035662, Molecular Function