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. Author manuscript; available in PMC: 2014 May 21.
Published in final edited form as: J Am Chem Soc. 2009 Jun 17;131(23):8211–8220. doi: 10.1021/ja901120f

Figure 10.

Figure 10

Sensing γDPGA with a nanopore that contained mAb F26G3 at the tip. A nanopore with mAb F26G3 was incubated with a solution of γDPGA for 3 hours, and the current voltage-voltage curves were measured in 10 mM KCl. Depending on pH of the solution, different surface charge patterns were formed on the pore walls (see the schematics in the upper part of the figure), which led to different current-voltage curves. At pH > 4, the polypeptide was negatively charged thus the current-voltage curves reversed compared to the situation before the γDPGA binding (see Fig. 9).