Table 2.
Drug susceptibilities of Mycobacterium tuberculosis isolates from index case (IC) and household contact (HC) cases in the Philippines
| |
First line drugs
a
|
Second line drugs |
|||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
Household/index contacts |
INH |
RIF |
EMB |
PZA |
STR |
CAP |
KAN |
AMI |
ETH |
CYC |
PAS |
||
| 0.2 | 1.0 | 1.0 | 7.5 | 300 | 2.0 | 10 | 10 | 6.0 | 6.0 | 10 | 60.0 | 8.0 | |
| IC1 |
R |
R |
R |
R |
R |
S |
S |
S |
S |
S |
S |
S |
S |
| HC1 |
R |
R |
S |
S |
S |
S |
S |
S |
S |
S |
S |
S |
S |
| IC2 |
R |
R |
R |
R |
R |
R |
R |
S |
S |
S |
S |
S |
S |
| HC2 |
R |
R |
R |
S |
S |
R |
R |
S |
S |
S |
S |
S |
S |
| IC3 |
R |
S |
R |
S |
S |
R |
R |
S |
S |
S |
S |
S |
S |
| HC3 |
R |
R |
R |
S |
S |
S |
S |
S |
S |
S |
S |
S |
S |
| IC4 |
R |
R |
R |
S |
N/Ab |
R |
S |
S |
S |
S |
R |
S |
S |
| HC4 |
R |
R |
S |
S |
S |
R |
S |
S |
S |
S |
S |
S |
S |
| IC5 |
R |
R |
R |
R |
R |
R |
R |
S |
S |
S |
S |
S |
S |
| HC5 |
R |
R |
R |
R |
R |
R |
R |
S |
S |
S |
S |
S |
S |
| IC6 |
R |
R |
R |
R |
R |
R |
R |
S |
S |
S |
R |
S |
S |
| HC6.1 |
R |
R |
R |
R |
S |
R |
R |
S |
S |
S |
R |
S |
S |
| HC6.2 |
R |
R |
R |
R |
S |
R |
R |
S |
S |
S |
R |
S |
S |
| HC6.3 |
S |
S |
S |
S |
S |
S |
S |
S |
S |
S |
S |
S |
S |
| IC7 |
R |
S |
R |
R |
S |
R |
R |
S |
S |
S |
R |
S |
S |
| HC7.1 |
S |
S |
S |
S |
S |
S |
S |
S |
S |
S |
S |
S |
S |
| HC7.2 |
S |
S |
S |
S |
S |
S |
S |
S |
S |
S |
S |
S |
S |
| IC8 |
R |
S |
S |
S |
S |
S |
S |
S |
S |
S |
S |
S |
S |
| HC8 |
S |
S |
S |
S |
R |
S |
S |
S |
S |
S |
S |
S |
S |
| IC9 |
R |
R |
R |
R |
R |
R |
R |
S |
S |
S |
S |
S |
S |
| HC9 |
R |
R |
R |
R |
R |
R |
R |
S |
S |
S |
S |
S |
S |
| IC10 |
R |
S |
S |
S |
S |
S |
S |
S |
S |
S |
S |
S |
S |
| HC10 |
R |
S |
S |
S |
S |
S |
S |
S |
S |
S |
S |
S |
S |
| IC11 |
S |
S |
S |
S |
S |
S |
S |
S |
S |
S |
S |
S |
S |
| HC11 |
R |
R |
R |
S |
S |
S |
S |
R |
S |
S |
R |
S |
S |
| IC12 |
R |
R |
R |
R |
R |
R |
R |
R |
S |
S |
S |
S |
S |
| HC12 |
R |
R |
R |
R |
S |
R |
R |
R |
S |
S |
S |
S |
S |
| IC13 |
R |
R |
R |
R |
S |
R |
S |
S |
S |
S |
S |
S |
S |
| HC13 | R | R | R | R | S | S | S | S | S | S | S | S | S |
Susceptibilities are reported in μg/mL.
Abbreviations: INH – isoniazid, RIF – rifampin, EMB – ethambutol, PZA – pyrazinamide, STR – streptomycin, CAP – capreomycin, KAN – kanamycin, AMI – amikacin, ETH – ethionamide, CYC – cycloserine, PAS – para-aminosalicylic acid; R – resistant, S – susceptible.
aWith the exception of PZA, susceptibility for all drugs was performed by the 1% indirect agar proportion method. PZA susceptibility was performed on the VersaTREK (TREK Diagnostics, Cleveland, OH).
bIsolate unable to grow in test medium for PZA susceptibility testing.