Table 1.
fMRI-Regions of interest analysis (ROIs) identified from Multi-Subject Fixed Effects GLM analysis (Figure 2).
| Item | ROI | Volume | X | Y | z | t-value sham | t-value rTMS |
|---|---|---|---|---|---|---|---|
| rTMS > SHAM | |||||||
| 1 | L MFG BA6 | 2250 | −12 | −10 | 58 | t = 28.03, p < 0.001 | t = 44.54, p < 0.001 |
| 2 | L M1 BA4 | 2107 | −22 | −21 | 62 | t = −4.09, p = NS | t = 12.30, p < 0.001 |
| 3 | L SPL BA5 cluster 1 | 2648 | −27 | −42 | 59 | t = 16.84, p < 0.001 | t = 33.23, p < 0.001 |
| 4 | L SPL BA5 cluster 2 | 1851 | −32 | −38 | 43 | t = 25.89, p < 0.001 | t = 36.25, p < 0.001 |
| 5 | L SoG BA19 | 1876 | −24 | −76 | 30 | t = 41.74, p < 0.001 | t = 57.64, p < 0.001 |
| 6 | L Precuneus BA7 | 4923 | −11 | −69 | 49 | t = 8.58, p < 0.001 | t = 24.45, p < 0.001 |
| 7 | L Cuneus BA18 | 5577 | −7 | −78 | 22 | t = −27.79, p < 0.001 | t = −7.47, p < 0.001 |
| 8 | L Lingual BA17 | 2137 | −6 | −89 | 1 | t = 13.82, p < 0.001 | t = 30.18, p < 0.001 |
| 9 | L MT | 1819 | −43 | −70 | 3 | t = 63.70, p < 0.001 | t = 76.45, p < 0.001 |
| SHAM > rTMS | |||||||
| 10 | L PMC BA6 | 2423 | −31 | −2 | 48 | t = 39.80, p < 0.001 | t = 20.94, p < 0.001 |
| 11 | L IPL BA40 Cluster2 | 667 | −41 | −33 | 38 | t = 31.93, p < 0.001 | t = 16.68, p < 0.001 |
| 12 | L IPL BA40 Cluster3 | 1103 | −51 | −41 | 41 | t = 0.68, p = NS | t = −9.30, p < 0.001 |
| 13 | L IPL BA40 Cluster5 | 650 | −39 | −52 | 45 | t = −1.66, p = NS | t = −9.66, p < 0.001 |
| 14 | L IPS BA39 | 1318 | −33 | −62 | 43 | t = −0.02, p = NS | t = −10.1, p < 0.001 |
| 15 | L Angular Gyrus BA39 | 2124 | −34 | −79 | 31 | t = 16.64, p < 0.001 | t = 5.41, p < 0.001 |
| 16 | L MoG BA19 | 1069 | −30 | −84 | 18 | t = 55.86, p < 0.001 | t = 39.44, p < 0.001 |
| rTMS > SHAM | |||||||
| 17 | R MFG BA6 | 967 | 7 | 10 | 49 | t = 25.48, p < 0.001 | t = 38.54, p < 0.001 |
| 18 | R IPL BA 40 | 3035 | 41 | −39 | 48 | t = 22.38, p < 0.001 | t = 35.49, p < 0.001 |
| 19 | R IPS | 3178 | 32 | −71 | 41 | t = 3.63, p = NS | t = 21.43, p < 0.001 |
| 20 | R Precuneus BA7 Cluster1 | 1309 | 11 | −72 | 55 | t = 14.46, p < 0.001 | t = 26.95, p < 0.001 |
| 21 | R Precuneus BA7 Cluster2 | 872 | 25 | −81 | 42 | t = 34.14, p < 0.001 | t = 43.91, p < 0.001 |
| 22 | R Precuneus BA31 | 719 | 19 | −60 | 25 | t = −19.00, p < 0.001 | t = −8.77, p < 0.001 |
| 23 | R Cuneus BA 18 | 4987 | 8 | −71 | 11 | t = −21.76, p < 0.001 | t = −5.48, p < 0.001 |
| 24 | R MoG BA19 | 743 | 29 | −87 | 7 | t = 16.08, p < 0.001 | t = 27.47, p < 0.001 |
| SHAM > rTMS | |||||||
| 25 | R PMC BA6 | 1970 | 23 | −2 | 51 | t = 45.419, p < 0.001 | t = 25.296, p < 0.001 |
| 26 | R MFG BA6 Cluster1 | 985 | 39 | −7 | 49 | t = 56.827, p < 0.001 | t = 39.885, p < 0.001 |
| 27 | R IFG BA6 | 1119 | 44 | 4 | 24 | t = 31.85, p < 0.001 | t = 16.172, p < 0.001 |
| 28 | R SPL BA 5 | 812 | 26 | −40 | 54 | t = 33.862, p < 0.001 | t = 23.058, p < 0.001 |
| 29 | R SoG BA19 | 632 | 23 | −79 | 27 | t = 47.460, p < 0.001 | t = 34.959, p < 0.001 |
| 30 | R Lingual Gyrus BA18 | 611 | 8 | −75 | −5 | t = 45.970, p < 0.001 | t = 31.715, p < 0.001 |
| 31 | R MT | 1482 | 44 | −72 | 10 | t = 50.504, p < 0.001 | t = 34.403, p < 0.001 |
ROIs and their clusters, location (Talairach x, y, and z in mm) and intensities following concatenated runs (1, 2, and 3) of rTMS vs. sham. PMC, premotor cortex; M1 primary motor cortex; IPL, inferior parietal lobule; SPL, superior parietal lobule; IPS, intra parietal sulcus; MT, medial temporal; SoG, superior occipital gyrus; MoG, medial occipital gyrus; MFG, middle frontal gyrus; IFG, inferior frontal gyrus; AG, angular gyrus. Items 1–18: areas in the left hemisphere and items 17–31: areas in the right hemisphere.