Fig. 2.

Work flow of reaction identification and iterative splitting approaches. Initially, the list of identified preliminary reactions for splitting is empty but increases by one reaction per loop through preliminary reaction identification. The final quantity of reactions for splitting was adjusted at the gray box by choosing route A if a predefined R was achieved or route B if more reactions for splitting were required. Depicted processes describe the pseudo-code or MATLAB functions listed in parentheses. See the Symbols Section for additional variable definitions