Fig. 1.

General workflow in annotation-guided DNA copy number analysis on SegAnnDB. Scatterplots of black points show log ratio as a function of genomic position. Breakpoints in the current segmentation are shown with vertical dashed lines, and predicted copy number status of each horizontal line segment is indicated by its color (Supplementary Table S2). Annotated regions can be added to update the copy number (top) and breakpoints (bottom) in the displayed model. Dragging on an unannotated region creates a new region with Save and Delete buttons, as shown for the normal region in the center. Before saving, the annotation can be changed by clicking the region. After saving, the displayed model is immediately updated to agree with the annotation