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. Author manuscript; available in PMC: 2014 May 21.
Published in final edited form as: Birth Defects Res A Clin Mol Teratol. 2014 Feb 27;100(4):250–259. doi: 10.1002/bdra.23228

TABLE 3.

Distribution of Age, Sex, Type of Craniosynostosis and Identified Mutations by Phenotype.

N (F;M) Mean Age in Months (SD) Type of Craniosynostosis (N) Genetic Data (N)
Apert 21 (11;10) 6.3 (6.6) BCS (16); BCS+LULS (2); BCS+RULS (1); RUCS (1); None (1) FGFR2S252W (7); FGFR2P253R (3)
Crouzon 9 (3;6) 6.0 (3.3) BCS (1); BCS+BLS+SS (1); BLS (1); RUCS (2); RUCS+BLS+SS (1); None (3) FGFR2F276V (1)
Pfeiffer 7 (5;2) 7.3 (7.9) BCS (2); BCS+BLS (1); BCS+SS (1); LUCS (2); LUCS+SS (1) FGFR2A172F (1); FGFR2C342R (1)
Muenke 6 (3;3) 4.8 (2.6) BCS (3); BCS+LULS (1); RUCS (2) FGFR3P250R (6)
Unaffected 20 (10;10) 10.7 (6.8) None (20)

BCS, bicoronal synostosis; BLS, bilambdoid synostosis; SS, sagittal synostosis; RUCS, right unicoronal synostosis; LUCS, left unicoronal synostosis; LULS, left unilambdoid synostosis; None, no sign of craniosynostosis.