. Author manuscript; available in PMC: 2014 May 21.

Published in final edited form as: Birth Defects Res A Clin Mol Teratol. 2014 Feb 27;100(4):250–259. doi: 10.1002/bdra.23228

TABLE 4.

Procrustes Distances between Groups and Corresponding p-Values after Permutation Test with 10,000 Rounds.

Faces of the genotyped cases
	FGFR2^P253R	FGFR2^S252W	FGFR3^P250R
FGFR2^S252W	0.074 (0.1564)
FGFR3^P250R	0.0915 (0.1169)	0.0866 (0.0033)
None	0.1414 (0.0004)	0.1601 (<0.0001)	0.0964 (<0.0001)
Skulls of the genotyped cases
	FGFR2^P253R	FGFR2^S252W	FGFR3^P250R
FGFR2^S252W	0.0531 (0.407)
FGFR3^P250R	0.06 (0.379)	0.0598 (0.0872)
None	0.1462 (0.0001)	0.1491 (<0.0001)	0.1225 (<0.0001)
Faces of the genotyped and clinically diagnosed cases
	Apert	Crouzon	Muenke	Pfeiffer
Crouzon	0.0908 (<0.0001)
Muenke	0.0661 (0.0104)	0.0788 (0.004)
Pfeiffer	0.0774 (0.0011)	0.0612 (0.0863)	0.0661 (0.1254)
Unaffected	0.1339 (<0.0001)	0.0795 (<0.0001)	0.0963 (<0.0001)	0.0829 (<0.0001)
Skulls of the genotyped and clinically diagnosed cases
	Apert	Crouzon	Muenke	Pfeiffer
Crouzon	0.105 (<.0001)
Muenke	0.0484 (0.0951)	0.095 (0.0001)
Pfeiffer	0.0681 (0.003)	0.0647 (0.0082)	0.0672 (0.0713)
Unaffected	0.1459 (<0.0001)	0.0888 (<0.0001)	0.1225 (<0.0001)	0.1016 (<0.0001)