Figure 3.

The principal players in the discovery of ICI 46,474 at ICI Pharmaceuticals Division, Cheshire, UK in the 1960’s that eventually evolved into tamoxifen a decade later. Arthur Walpole (Walop) (left) was the head of the Fertility Control Program tasked with the mission to discover safer compounds to “regulate the sexual cycle”. Dora Richardson (center), the team organic chemist who synthesized all of the isomers of the triphenylethylene derivatives that would be tested as antifertility agents in rats by Mike Harper, the team reproductive endocrinologist. Arthur Walpole would be the author’s PhD examiner, scientific supporter and administrative link to ICI until his untimely death on July 2^nd 1977. Dora Richardson would provide the metabolites of tamoxifen to the author to be tested as anticancer agents and Mike Harper would offer the author a two year BTA (Been to America) at the Worcester Foundation, MA. Each individual was generous with important opportunities, investment and support for a young investigator starting their adventure to investigate “failed morning after pills” as future important therapeutic agents in women’s health.