Table 5.
Significantly enriched GO (gene ontology) functional annotation of predicted target genes of differentially expressed miRNAs during E. coli or S. aureus challenge of MAC-T cells
| GO functional annotation | miRNA | # genes | *P-value (**Benjamini P-Value) | miRNA | # genes | P-value (Benjamini P-Value) |
|---|---|---|---|---|---|---|
| Biological adhesion |
Bta-miR-23a |
58 |
0.038 (0.11) |
- |
- |
- |
| Biological regulation |
Bta-miR193a-3p |
159 |
0.002 (0.039) |
Bta-miR-24-3p |
287 |
0.010 (0.070) |
| |
Bta-miR365-3p |
142 |
5.5E-5 (3.9E-4) |
Bta-miR-148a |
356 |
1.7E-8 (1.3E-7) |
| |
Bta-miR-30b-5p/30c |
642 |
4.4E-6 (3.2E-5) |
Bta-miR-23a |
565 |
4.0E-9 (4.2E-8) |
| |
Bta-miR-499 |
135 |
0.045 (0.11) |
Bta-miR-92a |
441 |
7.2E-10 (1.6E-8) |
| |
Bta-miR-99b |
31 |
0.007 (0.060) |
- |
- |
- |
| Cellular component organization |
Bta-miR-30b-5p/30c |
235 |
2.4E-4 (0.001) |
Bta-miR-2339 |
46 |
0.002 (0.016) |
| Bta-let-7a-5p |
182 |
0.040 (0.120) |
Bta-miR-23a |
192 |
0.004 (0.016) |
|
| |
Bta-miR-499 |
60 |
0.001(0.008) |
Bta-miR-92a |
144 |
0.016 (0.049) |
| |
Bta-miR-148a |
127 |
9.4E-4 (0.005) |
Bta-miR-184 |
22 |
0.006 (0.080) |
| Cellular process |
Bta-miR193a-3p |
207 |
0.009 (0.096) |
Bta-miR-24-3p |
411 |
1.1E-6 (2.3E-5) |
| |
Bta-miR423-5p |
337 |
0.034 (0.160) |
Bta-miR-148a |
468 |
2.1E-9 (4.7E-8) |
| |
Bta-miR365-3p |
180 |
5.7E-4 (0.003) |
Bta-miR-2339 |
143 |
0.002 (0.020) |
| |
Bta-miR-30b-5p/30c |
889 |
1.1E-10 (2.5E-9) |
Bta-miR-23a |
766 |
1.1E-13 (2.4E-12) |
| |
Bta-let-7a-5p |
732 |
1.3E-5 (2.5E-4) |
Bta-miR-486-5p |
140 |
0.007 (0.067) |
| |
Bta-miR-499 |
198 |
8.2E-6 (1.6E-4) |
Bta-miR-92a |
567 |
2.0E-7 (1.4E-6) |
| |
Bta-miR-99b |
37 |
0.036 (0.100) |
- |
- |
- |
| Death |
Bta-miR193a-3p |
21 |
0.038 (0.190) |
Bta-miR-24-3p |
35 |
0.046 (0.220) |
| |
Bta-miR-30b-5p/30c |
70 |
0.031 (0.083) |
Bta-miR-21-3p |
7 |
0.044 (0.930) |
| |
Bta-let-7a-5p |
61 |
0.026 (0.087) |
Bta-miR-92a |
47 |
0.037 (0.084) |
| |
Bta-miR-499 |
21 |
0.014 (0.045) |
- |
- |
- |
| Developmental process |
Bta-miR193a-3p |
71 |
0.028 (0.190) |
Bta-miR-24-3p |
151 |
1.0E-5 (1.0E-4) |
| Bta-miR423-5p |
114 |
0.024 (0.150) |
Bta-miR-148a |
182 |
3.7E-9 (4.1E-8) |
|
| |
Bta-miR365-3p |
80 |
5.8E-7 (1.3E-5) |
Bta-miR-2339 |
57 |
7.1E-4 (0.015) |
| |
Bta-miR-30b-5p/30c |
312 |
9.1E-8 (1.0E-6) |
Bta-miR-23a |
272 |
2.2E-8 (1.5E-7) |
| |
Bta-let-7a-5p |
241 |
0.001 (0.008) |
Bta-miR-486-5p |
56 |
0.001 (0.022) |
| |
Bta-miR-499 |
74 |
4.1E-4 (0.004) |
Bta-miR-92a |
212 |
7.8E-8 (8.5E-7) |
| |
Bta-miR-99b |
19 |
0.002 (0.030) |
- |
- |
- |
| Establishment of localization |
Bta-miR423-5p |
110 |
3.4E-4 (0.007) |
Bta-let-7a-5p |
205 |
0.004 (0.011) |
| Bta-miR-30b-5p/30c |
243 |
9.9E-4 (0.004) |
Bta-miR-92a |
159 |
0.003 (0.009) |
|
| Growth |
Bta-miR-99b |
4 |
0.016 (0.088) |
Bta-miR-23a |
20 |
0.026 (0.088) |
| Localization |
Bta-miR423-5p |
119 |
8.8E-4 (0.009) |
Bta-miR-148a |
147 |
0.001 (0.005) |
| |
Bta-miR-30b-5p/30c |
280 |
7.0E-5 (3.9E-4) |
Bta-miR-2339 |
49 |
0.015 (0.078) |
| |
Bta-let-7a-5p |
233 |
7.2E-4 (0.008) |
Bta-miR-92a |
182 |
4.8E-4 (0.002) |
| |
Bta-miR-499 |
68 |
0.002 (0.008) |
- |
- |
- |
| Locomotion |
Bta-miR193a-3p |
14 |
0.049 (0.200) |
Bta-miR-92a |
31 |
0.030 (0.080) |
| |
Bta-miR-499 |
17 |
0.002 (0.009) |
- |
- |
- |
| Metabolic process |
Bta-miR365-3p |
139 |
9.6E-4 (0.004) |
Bta-miR-148a |
334 |
0.001 (0.006) |
| |
Bta-let-7a-5p |
538 |
0.001 (0.008) |
Bta-miR-23a |
559 |
1.8E-6 (9.7E-6) |
| |
Bta-miR-99b |
30 |
0.025 (0.081) |
Bta-miR-92a |
395 |
0.039 (0.084) |
| Multicellular organismal process |
Bta-miR365-3p |
94 |
2.3E-5 (2.4E-4) |
Bta-miR-24-3p |
167 |
0.050 (0.190) |
| Bta-miR-30b-5p/30c |
372 |
0.001 (0.004) |
Bta-miR-148a |
196 |
0.005 (0.015) |
|
| |
Bta-miR-499 |
84 |
0.027 (0.077) |
Bta-miR-92a |
258 |
2.2E-5 (1.2-E4) |
| Bta-miR-99b | 20 | 0.023 (0.095) | - | - | - |
*P-Value: The significance of gene-term enrichment with a modified Fisher’s Exact Test.
**Benjamini P-Value: Globally corrects enrichment p-values in order to control family-wide false discovery rate.