Table 3.

Multinomial mixed effect regression model of (log₁₀ +1) D. nodosus and (log₁₀ +1) F. necrophorum load in 18 sheep from one farm over weeks 5 weeks (274 observations).

Response	Interdigital dermatitis						Severe footrot
	Univariable			Multivariable			Univariable			Multivariable
Fixed part	OR	Lower 95% CI	Upper 95% CI	OR	Lower 95% CI	Upper 95% CI	OR	Lower 95% CI	Upper 95% CI	OR	Lower 95% CI	Upper 95% CI
Intercept
Week_2	Baseline
Week_3	0.48	0.16	1.44	0.44	0.13	1.43	0.76	0.16	3.61	1.75	0.31	10.05
Week_4	8.44	3.39	21.00	9.81	3.67	26.23	3.42	0.86	13.60	7.68	1.37	42.94
Week_5	6.63	2.66	16.48	6.15	2.25	16.85	2.99	0.73	12.17	6.73	1.26	36.01
Foot – left fore	Baseline
Foot – right fore	2.33	1.06	5.15	1.15	0.36	3.63	1.06	0.31	3.68	0.22	0.03	1.45
Foot – left hind	3.75	1.73	8.15	2.59	0.83	8.07	1.71	0.54	5.49	0.39	0.07	2.37
Foot – right hind	2.82	1.29	6.20	1.92	0.65	5.67	0.54	0.12	2.47	0.14	0.02	1.13
Log10 Dn load +1	1.20	1.05	1.37	1.28	1.08	1.53	1.04	0.85	1.29	0.97	0.75	1.26
Lag log10 Dn load +1	1.23	1.11	1.37	1.20	1.01	1.42	1.13	0.94	1.36	1.42	1.02	1.96
Log10 Fn load +1	0.95	0.84	1.07				1.18	0.92	1.51
(Log Fn load +1)2	0.99	0.97	1.01	0.99	0.96	1.02	1.04	1.00	1.08	1.06	1.01	1.11
Random part
Variance interdigital dermatitis (ID)	2.35	0.96	2.26	1.28
Co-variance ID/SFR	1.26	0.82	2.24	1.70
Variance severe footrot (SFR)	2.10	1.17	5.94	5.36

Dn = Dichelobacter nodosus, Fn = Fusobacterium necrophorum, Lag = week prior to disease onset, OR = odds ratio, CI = confidence interval, variables significant at 0.05 when CI do not include unity (Wald's test).