Table 3.
Comparison of mean pre and post-shift concentrations of 8-OHdG and Isoprostane among the exposed and reference groups and comparison of the mean of intraindividual differences between the exposed and the reference groups.
| Exposed group (N=61) | Reference group (N=37) | Comparison between groups |
|||||
|---|---|---|---|---|---|---|---|
|
|
|||||||
| post-shift mean (95% CI) |
pre-shift mean (95% CI) |
Mean of intraindividual post-preshift differences (95% CI) |
post-shift mean (95% CI) |
pre-shift mean (95% CI) |
Mean of intraindividual post-preshift differences (95% CI) |
Difference between the group means (95% CI) |
|
| Exposure | |||||||
| 1-OHP ng/ml | |||||||
| Smokers | 0.95 (0.37 to 1.52) | 0.69(0.44 to 0.94) | 0.26(−0.21 to 0.73) | 0.29(0.11 to 0.46) | 0.77(0.30 to 1.23) | −0.48(−0.83 to −0.14) | 0.74(−0.04 to 1.52) |
| Non-smokers | 0.69(0.25 to 1.12) | 0.46(0.25 to 0.66) | 0.23(−0.11 to 0.57) | 0.20(0.10 to 0.31) | 0.36(0.18 to 0.53) | −0.16(−0.37 to 0.05) | 0.39(−0.01 to 0.78) |
| Total | 0.84 (0.46 to 1.23) | 0.60 (0.43 to 0.77) | 0.25 (−0.17 to 0.66) | 0.23 (0.15 to 0.32) | 0.51 (0.31 to 0.72) | −0.28 (−0.50 to −0.06) | 0.53 (0.11 to 0.94) |
| Log(1-OHP) ng/ml | |||||||
| Smokers | −0.36(−0.53 to −0.19) | −0.32(−0.44 to −0.20) | −0.04(−0.18 to 0.10) | −0.69(−0.90 to −0.49) | −0.29(−0.53 to −0.06) | −0.40(−0.62 to −0.18) | 0.36(0.10 to 0.63) |
| Non-smokers | −0.48(−0.71 to −0.25) | −0.53(−0.71 to −0.35) | 0.05(−0.20 to 0.30) | −0.92(−1.12 to −0.72) | −0.67(−0.86 to −0.47) | −0.26(−0.51 to −0.002) | 0.31(−0.04 to 0.66) |
| Total | −0.41 (−0.54 to−0.27) | −0.41 (−0.51 to −0.30) | −0.004 (−0.17 to 0.16) | −0.84 (−0.98 to−0.69) | −0.52 (−0.68 to −0.37) | −0.31 (−0.52 to −0.10) | 0.31 (0.10 to 0.52 |
| Cotinine ng/ml | |||||||
| Smokers | 6744.9(4916.8 to 8573.0) | 8897.6(6891.9 to 10903.27) | −2152.7(−4372.2 to 67.8) | 3078.6(1107.0 to 5050.1) | 6547.9(535.3 to 12560.5) | −3469.3(−9154.8 to 2216.2) | 1316.6(−3486.7 to6119.9) |
| Non-smokers | 265.5(−233.7 to 764.7) | 109.0(−72.3 to 290.4) | 156.4(−162.6 to 475.4) | 8.1(5.9 to 10.4) | 9.2(6.3 to 12.1) | −1.1(−4.0 to 1.8) | 157.5(−175.4 to 490.5) |
| Total | 4109.2(2743.5 to 5474.8) | 5322.6(3694.8 to 6950.4) | −1213.4 (−3315.8 to 889.0) | 1182.1 (315.8 to 2048.4) | 2509.3 (132.5 to 4886.1) | −1327.2 (−3809.7 to 1155.4) | 113.8 (−2202.3 to 2429.9) |
| Log(cotinine) ng/ml | |||||||
| Smokers | 3.64(3.42 to 3.81) | 3.80(3.65 to 3.95) | −0.16(−0.27 to −0.06) | 3.15(2.72 to 3.58) | 3.46(3.10 to 3.81) | −0.31(−0.70 to 0.09) | 0.14(−0.13 to 0.42) |
| Non-smokers | 1.09(0.74 to 1.42) | 1.17(0.91 to 1.44) | −0.09(−0.35 to 0.16) | 0.77(0.56 to 0.98) | 0.71(0.40 to 1.01) | 0.06(−0.30 to 0.42) | −0.16(−0.58 to 0.26) |
| Total | 2.60 (2.23 to 2.97) | 2.73 (2.37 to 3.10) | −0.13 (−0.65 to 0.38) | 1.68 (1.23 to 2.13) | 1.76 (1.24 to 2.38) | −0.08 (−0.76 to 0.60) | −0.057(−0.304 to −0.191) |
|
| |||||||
| Outcome | |||||||
| 8OHdG ng/ml | |||||||
| Smokers | 10.03(7.84 to 12.21) | 17.97(15.52 to 20.42) | −7.94(−10.87 to −5.02) | 11.00(7.72 to 14.29) | 19.44(16.17 to 22.70) | −8.44(−13.07 to −3.80) | 0.49(−4.91 to 5.90) |
| Non-smokers | 10.18(7.29 to 13.07) | 13.78(11.02 to 16.54) | −3.60(−7.20 to −0.002) | 11.54(8.21 to 14.87) | 19.23(16.86 to 21.60) | −7.69(−9.82 to −5.56) | 4.09(−0.03 to 8.20) |
| Total | 10.09 (8.39 to 11.78) | 16.32 (14.46 to 18.19) | −6.23 (−8.73 to −3.74) | 11.34 (9.02 to 13.65) | 19.15 (17.33 to 20.98) | −7.82 (−10.72 to −4.92) | 1.74 (−1.56 to 5.03) |
| log(8-OHdG) ng/ml | |||||||
| Smokers | 0.88(0.65 to 1.00) | 1.22(1.15 to 1.28) | −0.33(−0.46 to −0.21) | 0.97(0.80 to 1.13) | 1.27(1.19 to 1.35) | −0.30(−0.48 to −0.12) | −0.03(−0.13 to 0.06) |
| Non-smokers | 0.90(0.75 to 1.04) | 1.10(1.01 to 1.18) | −0.20(−0.36 to −0.04) | 0.97(0.85 to 1.10) | 1.27(1.22 to 1.32) | −0.30(−0.40 to −0.19) | 0.10(−0.09 to 0.28) |
| Total | 0.89 (0.80 to 0.98) | 1.17 (1.12 to 1.22) | −0.28 (−0.39 to−0.18) | 0.97 (0.88 to 1.07) | 1.27 (1.22 to 1.31) | −0.29 (−0.40 to −0.19) | 0.01 (−0.12 to 0.16) |
| Isoprostane ng/ml | |||||||
| Smokers | 1.78(1.33 to 2.22) | 2.72(2.02 to 3.41) | −0.94(−1.61 to −0.27) | 1.97(1.12 to 2.83) | 2.55(2.07 to 3.04) | −0.58(−1.57 to 0.41) | −0.36(−1.59 to 0.86) |
| Non-smokers | 1.53(1.10 to 1.97) | 2.21(1.78 to 2.64) | −0.68(−1.18 to −0.17) | 1.52(1.24 to 1.79) | 2.23(1.71 to 2.76) | −0.72(−1.28 to 0.15) | 0.04(−0.69 to 0.77) |
| Total | 1.68(1.37 to 1.99) | 2.51(2.07 to 2.95) | −0.83(−1.27 to −0.40) | 1.69(1.34 to 2.04) | 2.35(1.99 to 2.71) | −0.66(−1.15 to −0.18) | −0.17(−0.84 to 0.50) |
| log(Isoprostane) ng/ml | |||||||
| Smokers | 0.14(0.04 to 0.25) | 0.36(0.27 to 0.44) | −0.22(−0.34 to −0.09) | 0.21(0.05 to 0.38) | 0.39(0.30 to 0.47) | −0.17(−0.37 to 0.02) | −0.04(−0.27 to 0.19) |
| Non-smokers | 0.08(−0.05 to 0.22) | 0.30(0.21 to 0.39) | −0.22(−0.35 to −0.08) | 0.15(0.06 to 0.23) | 0.29(0.19 to 0.40) | −0.15(−0.27 to −0.03) | −0.07(−0.25 to 0.11) |
| Total | 0.12 (0.04 to 0.20) | 0.33 (0.27 to 0.39) | −0.21 (−0.30 to −0.12) | 0.17 (0.10 to 0.25) | 0.33 (0.26 to 0.40) | −0.16 (−0.26 to −0.06) | −0.06 (−0.20 to −0.08) |