. Author manuscript; available in PMC: 2014 Nov 1.

Published in final edited form as: J Mol Biol. 2013 Aug 3;425(21):4023–4033. doi: 10.1016/j.jmb.2013.07.037

Table 3.

Comparison of prediction of HB-causing possibility using decision tree developed in this study and other software

F9 Test Set
	PolyPhen-2	SIFT-DNA	PROVEAN	Mutation Assessor	Condel	Decision Tree A
Sensitivity (%)	89.31	89.31	85.50	75.57	86.05	70.99
Specificity (%)	75.00	66.67	83.33	83.33	83.33	88.00
Accuracy (%)	88.11	87.41	85.31	76.22	85.82	73.72
Balanced accuracy (%)	82.16	77.99	84.41	79.45	84.69	79.50
Healthy synonymous mutations predicted	0/13	0/13	0/13	0/13	0/13	13/13

Note that synonymous mutations were not considered in statistical calculations for the other software.