. Author manuscript; available in PMC: 2014 Nov 1.

Published in final edited form as: J Mol Biol. 2013 Aug 3;425(21):4023–4033. doi: 10.1016/j.jmb.2013.07.037

Table 4.

Mutation composition of training and test sets

Data set	Gene	Hemophilia-causing mutations			Neutral variants	Mutation source
Data set	Gene	Severe	Moderate	Mild	Neutral variants	Mutation source
F8 Training Set	f8	233	0	0	102 + (40^a)	CHAMP, Santacroce et al. [24], dbSNP
F8 Test Set 1	f8	0	154	208	0	CHAMP
F8 Test Set 2	f8	169 + (1^a)	108 + (2^a)	160 + (7^a)	0	CHAMP
F9 Test Set	f9	86	25	23 + (3^a ^b)	25 + (13^a)	Katagiri et al. [15], dbSNP

Synonymous mutations are shown in parentheses.

Three synonymous mutations, V153V (g459a) [19], R162R (c484a), and Q237Q (a711g) (personal communication), are added to the mutations from Katagiri et al. 2012 [15].