ChIP analysis for Satb1 binding sites in the TH2 cytokine locus. This analysis revealed nine Satb1-binding sequences within the 200 kb TH2 locus (SBS-C1-C9). In addition, two other regulatory sequences (CNS-1 and CNS-2) were bound to Satb1. a, Schematic representation of the TH2 cytokine locus; b, Semiquantitative PCR; and c, Real-time PCR analyses of cross-linked chromatin from resting and activated D10.G4.1 cells purified by urea-gradient centrifugation, digested with Sau3AI, and precipitated with anti-Satb1.