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(a) Effect of coculture with human umbilical vein endothelial cells (HUVECs) on angiogenic factor secretion by 2D U2OS monoculture, 2D GFP-sorted U2OS cocultured with HUVECs, and 2D unsorted U2OS cocultured with HUVECs. **Statistically similar at p>0.05. (b) Upregulation of IL-8 and VEGF-A in 3D coculture with HUVECs. *Statistically different at p<0.05.
