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. 2014 Jan 7;22(1):9. doi: 10.1186/2008-2231-22-9

Scheme 1.

Scheme 1

Synthesis of coumarin based dihydrobenzothiazines 2a-u. Reagents and conditions: (a) phenacyl halide (1.2 mmol), KF/Al2O3 (0.7 g), quinine hydrochloride (10 mol%), EtOH (3 mL), r.t. (b) phenacyl halide (2.5 mmol), KF/Al2O3 (1.5 g), quinine hydrochloride (10 mol%), EtOH (3 mL), r.t.