Table 2.
Antinociception activity of selected compounds in comparison with mefenamic acid (30 mg/kg, i.p.) assessed by acetic acid-induced writhing test in mice
| Compound | Nociception (Mean ± SEM) | Inhibition (%) a | Relative activity b |
|---|---|---|---|
|
2b |
0.6 ± 0.24*** |
99 |
1.4 |
|
2c |
38 ± 4.04*** |
49 |
0.7 |
|
2d |
9.6 ± 2.54*** |
87 |
1.3 |
|
2g |
3.5 ± 1.09*** |
96 |
1.37 |
|
2h |
3 ± 1.84*** |
97 |
1.38 |
|
2i |
4.6 ± 2*** |
94 |
1.34 |
|
2k |
20 ± 2.48*** |
73 |
1.04 |
|
2o |
6 ± 3.2*** |
92 |
1.31 |
|
2r |
29 ± 2.12*** |
63 |
0.9 |
|
2s |
14 ± 2.28*** |
80 |
1.14 |
|
2t |
30 ± 7.6*** |
60 |
0.85 |
|
2u |
2 ± 1.3*** |
98 |
1.4 |
| Controlc |
75 ± 3.2 |
|
|
| Mefnamic acid | 23 ± 1.3*** | 70 |
aThe percentage inhibition was determined by using the following formula: Inhibition% = 100 × (control – experiment)/control.
bActivity relative to mefenamic acid was determined by using the following formula: Relative Activity = Inhibition % of compound/Inhibition % of mefenamic acid.
cTween 80 in saline (4% w/v).
***P <0.001 vs. control.