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. 2013 Dec 10;12:157. doi: 10.1186/1476-4598-12-157

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Copyright © 2013 Chen et al.; licensee BioMed Central Ltd.

This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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DKK1 regulates β-catenin expression through the non-canonical Wnt pathway. A: Restoration of DKK1 promoted the mRNA expression of β-catenin in HepG2 cells. B: Knockdown of DKK1 attenuated β-catenin mRNA expression in Bel7402 cells. C: Restoration of DKK1 promoted the protein levels of β-catenin and c-Myc in HepG2 cells. D: Knockdown of DKK1 attenuated the protein levels of β-catenin and c-Myc in Bel7402 cells. E: IWP-2 attenuated the positive effect of DKK1 on β-catenin expression in HepG2 cells. F: Treatment with GSK3β inhibitor LiCl restored the expression of β-catenin in Bel7402 cells.