TABLE 1.
Demographics and Sample Descriptive, (1) Asthma Compared with Normal Control and (2) Severe with Not severe Asthma Severity.
| Normal Controls (n=36) | Asthma (n=91) | Normal controls vs. Asthma (p-value) | Not severe (n=42) | Severe asthma (n=49) | Not severe vs. Severe Asthma (p-value) | |
|---|---|---|---|---|---|---|
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| Age, mean (SD) | 29.74 (9.64) | 39.09 (13.68) | <.0001 | 31.83 (11.32) | 45.32 (12.48) | <.0001 |
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| Female (%) | 18 (50.00) | 62 (68.13) | 0.07 | 29 (69.05) | 33 (67.35) | 0.86 |
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| Ethnicity (%) | ||||||
| Hispanic/Latino | 2 (5.56) | 3 (3.30) | 2 (4.76) | 1 (2.04) | ||
| Not Hispanic/Latino | 34 (94.44) | 88 (96.70) | 0.62 | 40 (95.24) | 48 (97.96) | 0.59 |
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| Race (%) | ||||||
| White | 29 (80.56) | 67 (73.63) | 28 (66.67) | 39 (79.59) | 0.24 | |
| Black | 3 (8.33) | 14 (15.38) | 0.63 | 7 (16.67) | 7 (14.29) | |
| Other | 4 (11.11) | 10 (10.99) | 7 (16.67) | 3 (6.12) | ||
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| BMI, mean (SD) | 25.51 (4.54) | 29.14 (6.75) | 0.0007 | 28.51 (6.98) | 29.69 (6.57) | 0.41 |
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| Education, (%) | ||||||
| <College | 1 (3.23) | 15 (16.67) | 4 (9.52) | 11 (22.92) | 0.10 | |
| ≥College | 30 (96.77) | 70 (77.78) | 0.05 | 37 (88.10) | 33 (68.75) | |
| Other | 0 | 5 (5.56) | 1 (2.38) | 4 (8.33) | ||
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| Baseline FEV1 (mean (SD)) | 99.25 (8.87) | 70.99 (24.50) | <.0001 | 86.83 (17.03) | 57.41 (21.67) | <.0001 |
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| Disease Control (mean (SD)) | N/A | N/A | N/A | 17.24 (5.70) | 28.05 (8.87) | <.0001 |
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| Asthma Onset (mean (SD)) | N/A | N/A | N/A | 12.67 (12.41) | 19.96 (18.62) | 0.03 |
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| OCS steroid use (%) | ||||||
| No | N/A | N/A | N/A | 42 (100) | 10 (20.41) | <.0001 |
| Yes | 0 | 39 (79.59) | ||||