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. 2014 Jan 6;14:2. doi: 10.1186/1471-2466-14-2

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Copyright © 2014 Church et al.; licensee BioMed Central Ltd.

This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Observed LS mean trough FEV₁and simulated fitted model for UMEC QD and BID regimens. Data are for (a) UMEC QD in the mITT population, (b) UMEC QD in the mITT population excluding patients from one investigator site, (c) UMEC BID in the mITT population, and (d) UMEC BID in the mITT population excluding patients from one investigator site. CI, confidence interval; ED₅₀ (C₅₀), dose that yields 50% of E_max; E_max, maximum predicted FEV₁ response; FEV₁, forced expiratory volume in 1 second; Obs LS, observed least square; RSE, relative standard error.