Figure 2.

Charge deconvoluted apoA1 MSIA spectrum from an individual heterozygous for a rare genetic form of apoA1. The observed mass shift of +30 Da suggests that the mutation codes for the previously observed Ala37Thr form of apoA1 [84]. The specificity of antibody capture and observed mass that corresponds with a known human mutation, combined with prior population studies in which similar peak “splitting” has not been observed [21, 36] support the assertion that approximately half of the apoA1 represented in this spectrum carries a sequence-altering mutation.