Figure 6.

Example of predicted subnetworks. Nodes (with ID numbers of KEGG COMPOUND or KNApSAcK) represent molecules. Black bold lines indicate the predicted pairs that were considered as positive after manual examination. Black thin lines and gray lines indicate those that were considered suspicious and negative, respectively. (b) An example pair that was considered as positive, representing a cyclization reaction. (c) Another example pair considered as positive, representing a methylation reaction. (d) An example pair that was considered as suspicious, representing a hydroxylation reaction. (e) An example pair that was considered as negative, representing large rearrangement of carbon skeleton that seems impossible to occur.