TABLE 1.
Characteristics of participating studies and their grading methods
| Study | Examination periods |
N participants (N with gradable photos*) |
Angle and camera type/model used |
Fields photographed |
Grading processes |
Definition of early AMD |
|---|---|---|---|---|---|---|
| BDES | 1988-1990 | 4926 (4778) | 30° film Zeiss FF4 | ETDRS 1,2 (stereo); modified 3 (nonstereo) |
Preliminary, Detail, Edit, Adjudication, Longitudinal Review |
Any drusen size or type in the presence of pigmentary abnormalities or soft indistinct drusen ≥125 μm diameter |
| 1993-1995 | 3722 (3556) | 30° film Zeiss FF4 | ||||
| 1998-2000 | 2962 (2831) | 30° film Zeiss FF4 | ||||
| 2003-2005 | 2375 (2260) | 30° film Zeiss FF4 | ||||
| 2008-2010 | 1913 (1790) | 30° film Zeiss FF4 | ||||
|
| ||||||
| BMES | 1992-1994 | 3654 (3583) | 30° film Zeiss FF3 | ETDRS 1,2 (stereo) and four other fields |
Detail, Longitudinal Review | Soft distinct drusen ≥125 μm diameter in the presence of pigmentary abnormalities or soft indistinct drusen ≥125 μm diameter |
| 1997-1999 | 2334 (2307) | 30° film Zeiss FF3 | ||||
| 2002-2004 | 1952 (1689) | 30° film Zeiss FF3 | ||||
| 2007-2010 | 1149 (1050) | 40° digital Canon CF-60 DSi and Canon EoS 1DS Mark II |
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|
| ||||||
| LALES | 2000-2003 | 6357 (5875) | 30° film Zeiss FF450+ | ETDRS 1,2 (stereo); modified 3 (nonstereo) |
Preliminary, Detail, Edit, Adjudication, Longitudinal Review |
Any drusen size or type in the presence of pigmentary abnormalities or soft indistinct drusen ≥125 μm diameter |
| 2004-2008 | 4658 (3908) | 30° film Zeiss FF450+ | ||||
| 2010-date | 30° digital Topcon TRC-50DX | |||||
|
| ||||||
| RS | 1989-1993 | 6780 (6405) | 35° film Topcon TRV-50VT | ETDRS 1, 2 (stereo) |
Detail, Longitudinal Review | Soft distinct drusen ≥63 μm diameter in the presence of pigmentary abnormalities or soft indistinct drusen ≥125 μm diameter |
| 1993-1995 | 6315 (4932) | 35° film Topcon TRV-50VT | ||||
| 1997-1999 | 4797 (3625) | 35° film Topcon TRV-50VT | ||||
| 2000-2004 | 3550 (2662) | 35° digital Topcon TRC 50EX and Sony DXC-950P |
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| 2009-2011 | 1658 (1447) | 35° digital Topcon TRC 50EX and Sony DXC-950P |
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AMD, age-related macular degeneration; BDES, Beaver Dam Eye Study; BMES, Blue Mountains Eye Study; ETDRS, Early Treatment of Diabetic Retinopathy Study; LALES, Los Angeles Latino Eye Study; RS, Rotterdam Study.
*
In at least one eye.