TABLE 4.

Definitions of age-related macular degeneration lesions used globally across all four studies

Lesion	Global Definition
Large drusen size	≥ 125 pm in diameter
Large drusen area	≥ 650 pm in diameter
Increased pigment	Any AMD related increased pigment
RPE depigmentation	Any AMD related RPE depigmentation
Geographic atrophy	Area of atrophy ≥350 μm in diameter and presence of at least 2 of these features: sharp edge, lack of RPE, visible choroidal vessels, and circular shape
Exudative AMD	Presence of any of the following: pigment epithelial detachment and/or retinal detachment, subretinal hemorrhage, subretinal scar, subretinal new vessels, treatment for exudative lesion

AMD, age-related macular degeneration; RPE, retinal pigment epithelium.