TABLE 5.
The age-sex adjusted prevalence of early and late age-related macular degeneration in the four cohorts using the individual three grading center original definitions and the Three Continent AMD Consortium global definition
| BDES | BMES | RS | LALES | |||||
|---|---|---|---|---|---|---|---|---|
|
|
||||||||
| Lesion/Level | Original Definition % |
Consortium Definition % |
Original Definition % |
Consortium Definition % |
Original Definition % |
Consortium Definition % |
Original Definition % |
Consortium Definition % |
| Early AMD | 18.7 | 20.3 | 4.0 | 12.8 | 7.6 | 17.4 | 14.1 | 15.8 |
| Large drusen | 15.9 | 15.8 | 5.4 | 5.4 | 8.9 | 12.9 | 14.8 | 14.8 |
| Large drusen area | 6.7 | 4.0 | NA | 7.4 | NA | 10.6 | 3.0 | 3.0 |
| Increased retinal pigment | 12.4 | 12.4 | 9.1 | 9.1 | 7.5 | 7.5 | 4.7 | 4.7 |
| RPE depigmentation | 7.3 | 7.3 | 5.6 | 5.6 | 7.2 | 7.2 | 1.9 | 1.9 |
| Late AMD | 1.8 | 1.8 | 1.8 | 1.8 | 1.6 | 1.6 | 0.2 | 0.3 |
| Geographic atrophy | 0.6 | 0.6 | 0.6 | 0.6 | 0.7 | 0.7 | 0.2 | 0.2 |
| Neovascular AMD | 1.2 | 1.2 | 1.2 | 1.2 | 1.0 | 1.0 | 0.1 | 0.1 |
AMD, age-related macular degeneration; BDES, Beaver Dam Eye Study; BMES, Blue Mountains Eye Study; LALES, Los Angeles Latino Eye Study; NA, not applicable; RPE, retinal pigment epithelium; RS, Rotterdam Study.