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. 2013 Dec 13;12:162. doi: 10.1186/1476-4598-12-162

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Copyright © 2013 Salvi et al.; licensee BioMed Central Ltd.

This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Effects of the sorafenib treatment on HCC cell lines. The HepG2, HA22T/VGH, SKHep1C3 and HuH6 cell lines were treated with sorafenib (5, 10, 15 μM concentration) for 3 days (24, 48 and 72 h). The proliferation was inhibited in a dose-dependent manner in all the cell lines considered (A-D). The most responsive HCC cell line was HepG2 (the highest percentage of the inhibition of proliferation was 72% with 15 μM of sorafenib at T = 72 h) (A). Statistical significance was determined by one way ANOVA with Bonferroni correction ^*p < 0.05; ^***p < 0.001.