Table 3.

Baseline of included studies

Index	Standard mean difference 95% CI	Heterogeneity	Overall effect ( P value)
Immunomodulation
CD3+ T cells	0.07 [−0.30, 0.44 ]	I2 = 67%	Z = 0.35 (P = 0.72)
CD4+ T cells	−0.04 [−0.31, 0.24]	I2 = 52%	Z = 0.27 (P = 0.79)
CD8+ T cells	−0.01 [−0.19, 0.18]	I2 = 0%	Z = 0.08 (P = 0.94)
Natural killer cells	−0.38 [−1.39, 0.62]	I2 = 79%	Z = 0.75 (P = 0.45)
IL-2	0.05 [−0.21, 0.32]	I2 = 0%	Z = 0.39 (P = 0.70)
Bone marrow suppression
Hemoglobin	0.04 [−0.19, 0.27]	I2 = 0%	Z = 0.37 (P = 0.71)
Platelets	0.06 [−0.17, 0.29]	I2 = 0%	Z = 0.53 (P = 0.60)
White blood cells	0.07 [−0.11, 0.24 ]	I2 = 0%	Z = 0.75 (P = 0.45)
Clinical efficacy
Karnofsky performance score	−0.08 [−0.25, 0.09]	I2 = 0%	Z = 0.93 (P = 0.35)