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. 2013 Nov 1;4(6):135. doi: 10.1186/scrt346

Figure 3.

Figure 3

Ixmyelocel-T displays enhanced cholesterol-efflux capacity. Quantitative real-time PCR gene-expression analysis of scavenger receptors normalized to GAPDH (n ≥ 5). Expression of (A) ABCA1, (B) ABCG1, (C) ACAT1, and (D) CEH in THP-1 and ixmyelocel-T macrophages before and after lipid loading. (E) Cholesterol efflux of both THP-1 macrophages and ixmyelocel-T to the lipid acceptors ApoA-I and HDL3 (n ≥ 4). Values are presented as mean ± SEM relative to control; *P < 0.05, **P < 0.01, ***P < 0.001 versus THP-1 -Ac–LDL; #P < 0.05, ##P < 0.01 versus IXT -Ac–LDL. PCR, polymerase chain reaction; GAPDH, glyceraldehyde 3-phosphate dehydrogenase; ABC, ATP-binding cassette; ACAT, acyl-CoA:cholesterol acyl-transferase; CEH, cholesterol ester hydrolase; ApoA-I, apolipoprotein A-I; HDL, high-density lipoprotein; SEM, standard error of the mean; Ac-LDL, acetylated low-density lipoprotein.