Table 1.
Potential Vaccine Antigens of Moraxella catarrhalis
| Antigen | Molecular Mass, kDa | Putative Function and Other Features |
Mouse Pulmonary Clearancea |
Referenceb |
|---|---|---|---|---|
| MID/Hag | 200 | Adhesin, binds IgD, hemagglutinin | Yes | 82–95 |
| MchA1, MchA2 | 184, 201 | Filamentous hemagglutinin-like adhesin | 96, 97 | |
| MhaB1, MhaB2 McmA | 110 | Metallopeptidase-like adhesin | 98 | |
| OppA | ~80 | Oligopeptide permease | Yes | 79 |
| UspA2 | 62 (oligomer) | Binds complement, vitronectin, and laminin | Yes | 94, 99, 100 |
| Msp 75 | ~75 | Homology to succinic dehydrogenase | Yes | 77, 78 |
| McaP | 66 | Adhesin and phospholipase B | 101 | |
| OMP E | 50 | Possible fatty acid transport | ||
| OMP CD | 45 | OMP A–like protein, binds mucin, adhesin | Yes | 102–104 |
| M35 | 36.1 | Porin, conserved with one variable loop | ||
| OMP G1a | ~29 | Lipoprotein putative copper transport protein | ||
| OMP G1b | ~29 | Surface molecule | ||
| OlpA | 24 | Homologous with Neisseria Opa adhesins | 105 | |
| Msp 22 | ~22 | Surface lipoprotein | Yes | 77, 78 |
| Type IV pili | 16 | Adhesin, transformation, biofilm formation | 106, 107 | |
| Lipooligosaccharide | 2.5–4 | Detoxified form is potential vaccine antigen | Yes | 81, 108, 109 |
a
Indicates that immunization with antigen induces enhance clearance in the mouse pulmonary clearance model.
b
References from 2007 to present.