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. Author manuscript; available in PMC: 2015 Mar 1.
Published in final edited form as: Curr Environ Health Rep. 2014 Jan 14;1(1):1–10. doi: 10.1007/s40572-013-0005-5

Table 2.

Examples of environmental exposures contributed to TET regulation and 5-hydroxymethylation changes.

Environmental Exposures Observed changes References
Ascorbic Acid (Vitamin C) Increased TET1 and TET2 activity and increased 5hmC in mouse embryonic stem cells [33], [34]. [35]
Phenobarbital Increased 5hmC in mature mouse liver tissue [36]
Diethylstilbestrol Decreased 5hmC in mouse adult uterine tissue [37]
Hydroquinone Increased TET1 and 5hmC in human embryonic kidney cell culture [38]
House dust mite Increased 5hmC in mouse lung tissue [40]